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KMID : 0617819960060010001
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Journal of Wonkwang Oriental Medicine
1996 Volume.6 No. 1 p.1 ~ p.14
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Effects of Polyporus Umbellatus and Hoelen Water Extracts on the Renal Function, Plasma Renin Activity and Plasma Levels of Atrial Natriuretic Peptide and Aldosterone in Rats
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Abstract
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The aim of this experiments was to investigate the effect of Polyporus Umbellatus and Hoelen water extracts on the renal function, plasma renin activity and plasma levels of atrial natriuretic peptide and aldosterone in rats.
The results of this study were as follows:
1. Water balance decreased significantly after the administration of Polyporus Umbellatus 0.4㎖/㎏, and 0.8㎖/㎏.
2. Urine volume increased significantly after the administration of Polyporus Umbellatus water 0.4㎖/㎏, 0.8㎖/㎏ water extracts, but it decreased significantly after the administration of Hoelen 0.4㎖/㎏.
3. Urinary excretion of sodium increased significantly after the administration of Polyporus Umbellatus 0.4㎖/㎏ and Hoelen 0.8㎖/㎏.
4. Urinary excretion of potasium increased significantly after the administration of Polyporus Umbellatus 0.4, 0.8㎖/㎏ but it decreased significantly after the administration of Hoelen 0.4, 0.8㎖/㎏.
5. Urinary excretion of chloride increased significantly after the administration of Polyporus Umbellatus and Hoelen water extracts.
6. Free water clearance increased significantly after the administration of Polyporus Umbeilatus 0.8㎖/㎏ and Hoelen 0.4㎖/㎏.
7. Urinary excretion of creatinine increased significantly after the administration of Polyporus Umbellatus 0.4, 0.8㎖/㎏ and Hoelen 0.8㎖/㎏.
8. Plasma levels of atrial natriuretic peptide (ANP) increased significantly after the adminstration of Polyporus Umbellatus 0.4㎖, 0.8㎖/㎏, but it decreased significantly after the administration of Hoelen 0.4, 0.8㎖/㎏.
9. Plasma levels of aldosterone decreased significantly after the administration of Polyporus Umbellatus water extracts are related to the changes of glomerular fitration rate, urinary excretion of electrolytes and plasma levels of atrial natriuretic peptide and aldosterone.
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